Publications

Peer-reviewed research on extrachromosomal DNA in cancer.

2026 Nature Genetics

Micronuclear ecDNA constrains tumor cell fitness and is associated with favorable patient survival

Lotte Brückner, Robin Xu, Jun Tang, Aditi Gnanasekar, Alexander Herrmann, Ivy Tsz-Lo Wong, Shu Zhang, Fengyu Tu, Madison Pilon, Alexander Kukalev, Katharina Pardon, Olga Sidorova, Joshua Atta, Qinghao Yu, Giulia Montuori, Davide Pradella, Mila Ilić, Kentaro Suina, Marco Novais-Cruz, Sarah Kaltenbach, Denise Treue, Mădălina Giurgiu-Kraljič, Sergej Herzog, Ann-Sophie Hollinger, Nadine Wittstruck, Martina Fernandez, Nicole Wolozyn, Finnja Becker, Varvara-Rigina Louma, Xiaowei Yan, Rachel Schmargon, Jan R. Dörr, David Gamlin, Annika Lehmann, Dennis Gürgen, Matthias Richter, Frank Dubois, Fabrizio Simeoni, Betheney R. Pennycook, Alastair Hamilton, Ralph K. Lindemann, Courtney Dawes, Gabriel Balmus, Barbara Hero, Matthias Fischer, Vineet Bafna, Roel Verhaak, Geoffrey Wahl, Yang Liu, Richard P. Koche, Stamatis Papathanasiou, René Medema, Bastiaan Spanjaard, Andrea Ventura, Ana Pombo, Weini Huang, Monika Scheer, Benjamin Werner, Howard Y. Chang, Paul S. Mischel, Anton G. Henssen

Read study
2026 Nature

MMEJ repair of breaks at TA repeats maintains ecDNA and cancer fitness

David Billing, Monica Selvaraj, Megan E. Kelley, Gabriel Matos-Rodrigues, Benton Bailey, Finnja Becker, Gang Zhen, Matthew A. Myers, Alessandra Brambati, Oluchi Ezekwenna, Ashley Nichols, Yi-Zhen Jiang, Lucia Wang, Shih-Chun Wang, Marie-Claude Mathieu, Davide Pradella, Hugo Poirier, Elias Rodriguez-Fos, Stephen J. Morris, Michal Zimmermann, Elsa Callen, Michael Zinda, Andrea Ventura, John Maciejowski, Andrew McPherson, Sohrab P. Shah, Anton George Henssen, André Nussenzweig, Agnel Sfeir

Read study
2025 Cancer Discovery

Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon, Elias Rodriguez-Fos, Konstantin Helmsauer, Hui Hui, Susmita Mandal, Karin Purshouse, Lara Fankhänel, Bartolomeo Bosco, Bastiaan Spanjaard, Hannah Seyboldt, Laura Grunewald, Matthias Jürgen Schmitt, Dennis Gürgen, Viktoria Buck, Mathias T. Rosenfeldt, Frank P.B. Dubois, Simon Schallenberg, Annika Lehmann, Jessica Theißen, Sabine Taschner-Mandl, Arend Koch, Patrick Hundsdoerfer, Annette Künkele, Angelika Eggert, Matthias Fischer, Gaetano Gargiulo, Teresa G. Krieger, Lukas Chavez, Fabian Coscia, Benjamin Werner, Weini Huang, Anton G. Henssen, Jan R. Dörr

Read study
2025 Cancer Discovery

Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment

Wei Lv, Yuchen Zeng, Conghui Li, Yuan Liang, Huiying Tao, Yanfen Zhu, Xiaolong Sui, Yue Li, Shiqi Jiang, Qingqing Gao, Elias Rodriguez-Fos, Gino Prasad, Yuanmei Wang, Run Zhou, Zhe Xu, Xiaoguang Pan, Linlin Chen, Xi Xiang, Huajing Teng, Chaoyang Sun, Tianyu Qin, Wei Dong, Yongwei Li, Xun Lan, Xuesong Li, Lin Lin, Lars Bolund, Huanming Yang, Roel G.W. Verhaak, Bishoy M. Faltas, Jacob B. Hansen, Sihan Wu, Paul S. Mischel, Anton G. Henssen, Vineet Bafna, Jens Luebeck, Birgitte Regenberg, Yonglun Luo, Chunhua Lin, Peng Han

Read study
2024 Nature

Coordinated inheritance of extrachromosomal DNAs in cancer cells

King L. Hung, Matthew G. Jones, Ivy Tsz-Lo Wong, Ellis J. Curtis, Joshua T. Lange, Britney Jiayu He, Jens Luebeck, Rachel Schmargon, Elisa Scanu, Lotte Brückner, Xiaowei Yan, Rui Li, Aditi Gnanasekar, Rocío Chamorro González, Julia A. Belk, Zhonglin Liu, Bruno Melillo, Vineet Bafna, Jan R. Dörr, Benjamin Werner, Weini Huang, Benjamin F. Cravatt, Anton G. Henssen, Paul S. Mischel, Howard Y. Chang

Read study
2023 Nature Genetics

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells

Rocío Chamorro González, Thomas Conrad, Maja C. Stöber, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brückner, Eric van Leen, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E. Stefanova, King L. Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y. Chang, Hedwig E. Deubzer, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen

Read study
2022 Nature Genetics

Targeted profiling of human extrachromosomal DNA by CRISPR-CATCH

King L. Hung, Jens Luebeck, Siavash R. Dehkordi, Caterina I. Colón, Rui Li, Ivy Tsz-Lo Wong, Ceyda Coruh, Prashanthi Dharanipragada, Shirley H. Lomeli, Natasha E. Weiser, Gatien Moriceau, Xiao Zhang, Chris Bailey, Kathleen E. Houlahan, Wenting Yang, Rocío Chamorro González, Charles Swanton, Christina Curtis, Mariam Jamal-Hanjani, Anton G. Henssen, Julie A. Law, William J. Greenleaf, Roger S. Lo, Paul S. Mischel, Vineet Bafna, Howard Y. Chang

Read study
2022 Nature Genetics

The evolutionary dynamics of extrachromosomal DNA in human cancers

Joshua T. Lange, John C. Rose, Celine Y. Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, Kathryn E. Yost, Quanming Shi, Marcella L. Erb, Utkrisht Rajkumar, Sihan Wu, Sabine Taschner-Mandl, Marie Bernkopf, Charles Swanton, Zhe Liu, Weini Huang, Howard Y. Chang, Vineet Bafna, Anton G. Henssen, Benjamin Werner, Paul S. Mischel

Read study
2021 Nature

ecDNA hubs drive cooperative intermolecular oncogene expression

King L. Hung, Kathryn E. Yost, Liangqi Xie, Quanming Shi, Konstantin Helmsauer, Jens Luebeck, Robert Schöpflin, Joshua T. Lange, Rocío Chamorro González, Natasha E. Weiser, Celine Chen, Maria E. Valieva, Ivy Tsz-Lo Wong, Sihan Wu, Siavash R. Dehkordi, Connor V. Duffy, Katerina Kraft, Jun Tang, Julia A. Belk, John C. Rose, M. Ryan Corces, Jeffrey M. Granja, Rui Li, Utkrisht Rajkumar, Jordan Friedlein, Anindya Bagchi, Ansuman T. Satpathy, Robert Tjian, Stefan Mundlos, Vineet Bafna, Anton G. Henssen, Paul S. Mischel, Zhe Liu, Howard Y. Chang

Read study
2020 Nature Communications

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche

Read study
2019 Nature Genetics

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

Richard P. Koche, Elias Rodriguez-Fos, Konstantin Helmsauer, Martin Burkert, Ian C. MacArthur, Jesper Maag, Rocio Chamorro, Natalia Munoz-Perez, Montserrat Puiggròs, Heathcliff Dorado Garcia, Yi Bei, Claudia Röefzaad, Victor Bardinet, Annabell Szymansky, Annika Winkler, Theresa Thole, Natalie Timme, Katharina Kasack, Steffen Fuchs, Filippos Klironomos, Nina Thiessen, Eric Blanc, Karin Schmelz, Annette Künkele, Patrick Hundsdörfer, Carolina Rosswog, Jessica Theissen, Dieter Beule, Hedwig Deubzer, Sascha Sauer, Joern Toedling, Matthias Fischer, Falk Hertwig, Roland F. Schwarz, Angelika Eggert, David Torrents, Johannes H. Schulte, Anton G. Henssen

Read study